甲亢猫血清离子镁和总镁浓度的评估。
Evaluation of ionized and total serum magnesium concentrations in hyperthyroid cats.
作者信息
Gilroy Cornelia V, Horney Barbara S, Burton Shelley A, MacKenzie Allan L
机构信息
Department of Pathology and Microbiology, Atlantic Veterinary College, Charlottetown, Prince Edward Island C1A 4P3.
出版信息
Can J Vet Res. 2006 Apr;70(2):137-42.
Hyperthyroidism can increase the renal excretion of magnesium and thus cause hypomagnesemia in various species. Anaerobically collected blood samples from 15 hyperthyroid and 40 normal, healthy cats were analyzed with an ion-selective electrode analyzer and a serum biochemical analyzer. There was no significant difference in ionized or total serum magnesium concentration between the 2 groups, but there was a significant difference (P = 0.004) in the ratio of ionized to total serum magnesium concentrations between the healthy cats and the hyperthyroid cats with thyroxine (T4) concentrations at or above the median. There was a significant correlation (r = 0.894, P = 0.000) between the ionized and total magnesium concentrations in the hyperthyroid cats. The hyperthyroid cats had a significantly lower (P = 0.003) total serum protein concentration than the healthy cats. A significant negative correlation (r = -0.670, P = 0.006) was detected between the ionized magnesium and logarithmically transformed total T4 concentrations in the hyperthyroid cats, which suggests that the severity of hyperthyroidism may contribute to a decrease in the ionized magnesium concentration.
甲状腺功能亢进会增加镁的肾脏排泄，从而在各种物种中导致低镁血症。对15只甲状腺功能亢进的猫和40只正常健康的猫通过离子选择电极分析仪和血清生化分析仪对厌氧采集的血样进行分析。两组之间的离子化或总血清镁浓度没有显著差异，但在甲状腺素（T4）浓度等于或高于中位数的健康猫和甲状腺功能亢进的猫之间，离子化与总血清镁浓度的比值存在显著差异（P = 0.004）。甲状腺功能亢进的猫中离子化镁浓度与总镁浓度之间存在显著相关性（r = 0.894，P = 0.000）。甲状腺功能亢进的猫的总血清蛋白浓度显著低于健康猫（P = 0.003）。在甲状腺功能亢进的猫中，离子化镁与对数转换后的总T4浓度之间检测到显著负相关（r = -0.670，P = 0.006），这表明甲状腺功能亢进的严重程度可能导致离子化镁浓度降低。
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