甲状腺功能亢进猫血清中的碱性磷酸酶骨同工酶和骨钙素
Alkaline phosphatase bone isoenzyme and osteocalcin in the serum of hyperthyroid cats.
作者信息
Archer F J, Taylor S M
机构信息
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan.
出版信息
Can Vet J. 1996 Dec;37(12):735-9.
The effect of hyperthyroidism on serum markers for increased bone metabolism and turnover was evaluated in 36 cats with elevated serum levels of thyroxine and alkaline phosphatase. Serum was analyzed for total and ionized calcium and phosphorous. Alkaline phosphatase isoenzymes were separated by agarose gel electrophoresis and osteocalcin was measured by radioimmunoassay. Values for hyperthyroid cats were compared with those for healthy cats. Alkaline phosphatase bone isoenzyme was markedly increased in all 36 hyperthyroid cats. Osteocalcin was increased in 44% of the cats. There was no correlation among the magnitude of increase in alkaline phosphatase bone isoenzyme, osteocalcin, and serum thyroxine concentrations. Increased serum phosphorus was found in 35% of the cats. Total calcium was within the reference range in all cats, while 50% of the cats had reduced levels of serum ionized calcium. We conclude that hyperthyroid cats do have altered bone metabolism, although it is usually clinically insignificant.
在36只血清甲状腺素和碱性磷酸酶水平升高的猫中，评估了甲状腺功能亢进对血清中骨代谢和骨转换增加标志物的影响。对血清进行总钙、离子钙和磷的分析。通过琼脂糖凝胶电泳分离碱性磷酸酶同工酶，并用放射免疫法测定骨钙素。将甲状腺功能亢进猫的值与健康猫的值进行比较。在所有36只甲状腺功能亢进猫中，碱性磷酸酶骨同工酶均显著升高。44%的猫骨钙素升高。碱性磷酸酶骨同工酶、骨钙素和血清甲状腺素浓度升高幅度之间无相关性。35%的猫血清磷升高。所有猫的总钙均在参考范围内，而50%的猫血清离子钙水平降低。我们得出结论，甲状腺功能亢进猫确实存在骨代谢改变，尽管通常在临床上无显著意义。
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