Tsai Kate L, Murphy Keith E
Department of Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77845-4467, USA.
Can J Vet Res. 2006 Apr;70(2):148-50.
Canine hip dysplasia (CHD) is characterized by a malformation of the hip joint that leads to joint laxity and consequential degenerative joint disease. The most widely used method for diagnosis of CHD is the ventrodorsal hip-extended radiologic view, commonly referred to as the Orthopedic Foundation for Animals (OFA) method. The method of the University of Pennsylvania Hip Improvement Program (PennHIP), an alternative technique that is based on hip joint laxity, provides a quantitative assessment, the distraction index (DI), of the likelihood of the development of CHD because of increased laxity in the hip joint. Linear regression analysis showed that, across many breeds of dog, the incidence of CHD, as defined by the OFA, is positively correlated with the mean DI, the determination coefficient (r2) being 26%. We used families of Boykin spaniels (BSs) to determine the level of joint laxity in the breed and to conduct an initial whole-genome screening to identify markers that co-segregate with increased joint laxity. Although there was a positive correlation between the incidence of hip dysplasia and increased joint laxity, we did not find significant linkage in the 28 BSs that underwent genotyping, likely owing to the small size of the pedigree.
犬髋关节发育不良（CHD）的特征是髋关节畸形，导致关节松弛并进而引发退行性关节疾病。诊断CHD最广泛使用的方法是腹背位髋关节伸展X线视图，通常称为动物骨科基金会（OFA）方法。宾夕法尼亚大学髋关节改良计划（PennHIP）的方法是一种基于髋关节松弛度的替代技术，它提供了一个定量评估指标——牵张指数（DI），用于评估由于髋关节松弛度增加而患CHD的可能性。线性回归分析表明，在许多犬种中，由OFA定义的CHD发病率与平均DI呈正相关，决定系数（r2）为26%。我们利用博伊金猎犬（BS）家族来确定该犬种的关节松弛水平，并进行初步的全基因组筛选，以识别与关节松弛度增加共分离的标记。尽管髋关节发育不良的发病率与关节松弛度增加之间存在正相关，但我们在接受基因分型的28只BS中未发现显著的连锁关系，这可能是由于系谱规模较小所致。
