Seeger T, Emrich D, Sandrock D
Abteilung für Nuklearmedizin, Zentrum Radiologie, Universität Göttingen, FRG.
Nuklearmedizin. 1995 Aug;34(4):135-40.
In order to determine the effective radiation dose to be delivered by 131I in functional autonomy we have used the functional autonomous volume calculated from the global 99mTc thyroid uptake under exogenous or endogenous suppression before and 3 to 7 months after treatment. The radiation dose to the autonomous volume was calculated retrospectively in 131 patients with unifocal, multifocal and disseminated autonomy (75 hyperthyroid, 56 euthyroid) who received 131I treatment of 200-300 Gy to the total volume of the gland. It could be shown that at least 350 Gy to the autonomous volume are required to reach the desired effect of treatment which was dependent only on the radiation dose delivered to the functional autonomous volume.
为了确定功能性自主性甲状腺结节中¹³¹I 的有效辐射剂量，我们使用了在治疗前及治疗后 3 至 7 个月在外源性或内源性抑制下由全球⁹⁹ᵐTc 甲状腺摄取量计算出的功能性自主体积。对 131 例单灶性、多灶性和弥漫性自主性（75 例甲亢、56 例甲功正常）患者进行回顾性计算，这些患者接受了对腺体总体积给予 200 - 300 Gy 的¹³¹I 治疗，发现对自主体积至少需要 350 Gy 才能达到期望的治疗效果，而该效果仅取决于给予功能性自主体积的辐射剂量。
