Kasashima Satomi, Hiroshi Minato, Toshinori Mori, Yoshio Oda
Pathology Section, Kanazawa University Hospital.
J Cutan Pathol. 2006 May;33(5):389-94. doi: 10.1111/j.0303-6987.2006.00455.x.
A very rare case of cutaneous mixed tumor with numerous adipose tissue and hair follicular structures in a 67-year-old Japanese male was reported. A well-circumscribed tumor was in the subcutaneous tissue of the cheek and far from the parotid gland. Histologically, the tumor consisted of an admixture of the adipose tissue, fibromyxoid tissue with spindle cells, and branching tubular structures. Outer layers of ductal epithelial cells and single spindle cells were often in a transition, likely as typical mixed tumor. Branching ducts connected with keratinous cysts, strands of trichoblastic basophilic cells and clear cell nests. There was a gradual transition, between small-sized adipocytes and vacuolated spindle cells. No chondroid stroma was seen. To our knowledge, this tumor is the first case of a lipomatous mixed tumor with hair follicular differentiation. The case indicates an additional wide spectrum of histologic appearances of cutaneous mixed tumor.
报告了一例极为罕见的皮肤混合瘤，患者为一名67岁日本男性，肿瘤内有大量脂肪组织和毛囊结构。一个边界清晰的肿瘤位于脸颊皮下组织，远离腮腺。组织学上，肿瘤由脂肪组织、含梭形细胞的纤维黏液样组织以及分支管状结构混合而成。导管上皮细胞外层和单个梭形细胞常呈过渡状态，可能为典型的混合瘤。分支导管与角质囊肿、毛母质嗜碱性细胞条索和透明细胞巢相连。小尺寸脂肪细胞和空泡化梭形细胞之间存在逐渐过渡。未见软骨样间质。据我们所知，该肿瘤是首例具有毛囊分化的脂肪瘤样混合瘤。该病例表明皮肤混合瘤的组织学表现范围更广。
