Stashower Mitchell E
The Clinical Center of Northern Virginia, Fairfax, Virginia 22033, USA.
Dermatol Surg. 2006 Mar;32(3):380-6. doi: 10.1111/j.1524-4725.2006.32077.x.
The treatment of earlobe keloids has historically been suboptimal; characterized by discomfort, poor response, and high rates of recurrence. Keloids are characterized by increased fibroblast activity in the setting of an altered cytokine profile.
To investigate whether topical imiquimod 5% cream applied postoperatively after tangential excision can prevent recurrence of earlobe keloids.
Four patients with a total of eight large pedunculated earlobe keloids (five of which were recurrent lesions) were treated with debulking by tangential shave excision followed by daily application of imiquimod 5% cream for 6 weeks.
At 6 and 12 months post-treatment there was an excellent cosmetic result and no evidence of recurrence in any of the lesions. Patients with keloids that were itchy and painful were completely asymptomatic at the conclusion of the study.
In this pilot study, imiquimod 5% cream following tangential shave excision was efficacious for the treatment of earlobe keloids. Further study is warranted to confirm the utility of imiquimod 5% cream in the treatment of earlobe keloids, as illustrated herein.
耳垂瘢痕疙瘩的治疗一直以来效果欠佳，存在不适、反应差及复发率高等问题。瘢痕疙瘩的特征是在细胞因子谱改变的情况下成纤维细胞活性增加。
探讨在耳垂瘢痕疙瘩切线切除术后局部应用5%咪喹莫特乳膏是否能预防其复发。
4例患者共8个大的带蒂耳垂瘢痕疙瘩（其中5个为复发病变），先采用切线削除术减容，然后每日外用5%咪喹莫特乳膏，持续6周。
治疗后6个月和12个月时，所有病变均获得极佳的美容效果，且无复发迹象。研究结束时，原本瘙痒疼痛的瘢痕疙瘩患者完全无症状。
在这项初步研究中，切线削除术后应用5%咪喹莫特乳膏治疗耳垂瘢痕疙瘩有效。如本文所示，有必要进一步研究以证实5%咪喹莫特乳膏在治疗耳垂瘢痕疙瘩中的效用。
