Triebel F, Hercend T
Laboratoire d'Hémato-Immunologie, INSERM U333, Institut Gustave-Roussy, Villejuif.
Presse Med. 1991 Dec 14;20(43):2203-7.
The structure of the gamma and delta chains of the human T lymphocyte receptor has been studied extensively over the past three years. A directory of gamma/delta lymphocytes in different normal or pathological situations has been developed from the analysis of the different sub-populations of circulating (cytofluorometry) or tissue infiltrating (slice immunohistochemistry) gamma/delta T lymphocytes. It has been shown that the gamma and delta chains do not express a very polymorphic pattern; consequently, 2 or 3 anti-V or anti-V/J gamma or delta monoclonal antibodies are sufficient to evaluate any bias in the expression of this receptor in a given pathological situation. We present the genes coding for the gamma and delta chains, the proteins resulting from their expression, the different antibodies recognizing these proteins, the functions associated with gamma/delta + cells and finally certain pathological situations where an expression bias of the different gamma and delta chains has been described.
在过去三年里，人们对人类T淋巴细胞受体的γ链和δ链结构进行了广泛研究。通过对循环（细胞荧光测定法）或组织浸润（切片免疫组织化学）γ/δ T淋巴细胞不同亚群的分析，编制了不同正常或病理情况下γ/δ淋巴细胞的目录。研究表明，γ链和δ链没有表现出非常多态的模式；因此，2或3种抗V或抗V/Jγ或δ单克隆抗体足以评估在特定病理情况下该受体表达的任何偏差。我们介绍了编码γ链和δ链的基因、它们表达产生的蛋白质、识别这些蛋白质的不同抗体、与γ/δ +细胞相关的功能，以及最后描述了不同γ链和δ链表达偏差的某些病理情况。
