Lipska B K, Jaskiw G E, Karoum F, Phillips I, Kleinman J E, Weinberger D R
Clinical Brain Disorders Branch, National Institutes of Mental Health Intramural Research Program, Neuroscience Center at St. Elizabeths, Washington, DC 20032.
Pharmacol Biochem Behav. 1991 Sep;40(1):181-4. doi: 10.1016/0091-3057(91)90342-y.
To determine the influence of intrinsic neurons of the dorsal hippocampus on dopamine (DA) turnover in other limbic areas, DA and its metabolites were assayed in several brain areas 14 and 28 days after bilateral ibotenic acid (IA) lesions of the dorsal hippocampus in the rat. The locomotor response to d-amphetamine was also assessed. Spontaneous locomotion was increased 14 but not 28 days postoperatively. There was no change in d-amphetamine-induced locomotion at any time. Presynaptic indices of DA turnover in the medial prefrontal cortex, anteromedial striatum and nucleus accumbens were not affected by the lesion. Unlike lesions of the medial prefrontal cortex, deefferentation of the dorsal hippocampus does not increase DA turnover in the basal ganglia.
为了确定背侧海马的内在神经元对其他边缘区域多巴胺（DA）周转的影响，在大鼠双侧海马腹侧注射鹅膏蕈氨酸（IA）损伤后14天和28天，对几个脑区的DA及其代谢产物进行了测定。还评估了对d-苯丙胺的运动反应。术后14天自发运动增加，但28天未增加。在任何时候，d-苯丙胺诱导的运动均无变化。内侧前额叶皮质、前内侧纹状体和伏隔核中DA周转的突触前指标不受损伤影响。与内侧前额叶皮质损伤不同，背侧海马去传入并不会增加基底神经节中的DA周转。
