Wilkinson L S, Mittleman G, Torres E, Humby T, Hall F S, Robbins T W
Department of Experimental Psychology, University of Cambridge, UK.
Behav Brain Res. 1993 Jun 30;55(2):143-50. doi: 10.1016/0166-4328(93)90110-c.
This study tested the hypothesis that the hippocampus modulates dopamine-dependent function of the nucleus accumbens using behavioural and neurochemical evidence. Rats with bilateral lesions of the hippocampus induced by colchicine and kainic acid exhibited equivalent levels of spontaneous locomotor activity but a potentiation of the hyperactivity produced, dose-dependently, by D-amphetamine measured in photo-cell activity cages. The same rats subsequently received unilateral implantations of a microdialysis probe aimed at the nucleus accumbens and showed elevated levels of extracellular dopamine in response to D-amphetamine but no significant difference in basal values in comparison with sham-operated controls. The results are discussed in terms of functional interactions between the hippocampus and nucleus accumbens involving the control of mesolimbic dopamine release.
本研究利用行为学和神经化学证据，验证了海马体调节伏隔核多巴胺依赖性功能这一假说。用秋水仙碱和 kainic 酸诱导产生双侧海马体损伤的大鼠，表现出同等水平的自发运动活性，但在光电活动笼中测量发现，D - 苯丙胺剂量依赖性地诱导产生的多动增强。随后，同样这些大鼠接受了针对伏隔核的微透析探针单侧植入，结果显示，与假手术对照组相比，它们对 D - 苯丙胺的反应是细胞外多巴胺水平升高，但基础值无显著差异。我们从海马体与伏隔核之间涉及中脑边缘多巴胺释放控制的功能相互作用方面对这些结果进行了讨论。
