Baeza M R, Barkley H T, Fernandez C H
Radiology. 1975 Jul;116(1):151-4. doi: 10.1148/116.1.151.
Sixty-two patients with pulmonary metastases from a variety of primary malignant neoplasms were treated with total-lung irradiation. The incidence of radiation pneumonitis was 21%(13/62) overall, rising to 23% (9/39) in those receiving a tumor dose of 1,500 rads or more. Nine patients with radiation pneumonitis were given chemotherapy (actinomycin D) together with irradiation, and in this group the incidence of radiation pneumonitis was 25%. Five survivors, including 4 treated for metastatic Wilms' tumor, were treated more than 13 months prior to analysis without evidence of disease thus far. Total-lung irradiation for primary malignant neoplasms other than Wilms' tumor does not presently appear to be indicated. A dose of 1,500 rads in 2 weeks in conjunction with actinomycin D is recommended for metastatic Wilms' tumor.
62例患有各种原发性恶性肿瘤肺转移的患者接受了全肺照射。放射性肺炎的总体发生率为21%（13/62），在接受1500拉德或更高肿瘤剂量的患者中升至23%（9/39）。9例放射性肺炎患者在接受照射的同时接受了化疗（放线菌素D），该组放射性肺炎的发生率为25%。5名幸存者，包括4名接受转移性肾母细胞瘤治疗的患者，在分析前13个月以上接受治疗，目前尚无疾病证据。目前似乎不建议对除肾母细胞瘤以外的原发性恶性肿瘤进行全肺照射。对于转移性肾母细胞瘤，建议在2周内给予1500拉德的剂量并联合放线菌素D。
