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瑞典一家大学医院中艰难梭菌的抗菌药物敏感性模式及其与PCR核糖型的关系。

Antimicrobial susceptibility pattern of Clostridium difficile and its relation to PCR ribotypes in a Swedish university hospital.

作者信息

Aspevall Olle, Lundberg Annika, Burman Lars G, Akerlund Thomas, Svenungsson Bo

机构信息

Department of Clinical Microbiology, Akademiska University Hospital, SE-751 85 Uppsala, Sweden.

出版信息

Antimicrob Agents Chemother. 2006 May;50(5):1890-2. doi: 10.1128/AAC.50.5.1890-1892.2006.

DOI:10.1128/AAC.50.5.1890-1892.2006
PMID:16641471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1472208/
Abstract

All 238 Clostridium difficile isolates were susceptible to metronidazole and vancomycin, whereas 84% and 1% were resistant to clindamycin and fusidic acid. Etest MICs for metronidazole were lower than agar dilution MICs (P < 0.01) but without difference in susceptible-intermediate-resistant categorization. No particular PCR ribotype was associated with clindamycin or fusidic acid resistance.

摘要

所有238株艰难梭菌分离株对甲硝唑和万古霉素敏感，而对克林霉素和夫西地酸的耐药率分别为84%和1%。甲硝唑的Etest最低抑菌浓度低于琼脂稀释法最低抑菌浓度（P < 0.01），但在敏感-中介-耐药分类方面无差异。没有特定的PCR核糖型与克林霉素或夫西地酸耐药相关。

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Lancet. 2005;366(9491):1079-84. doi: 10.1016/S0140-6736(05)67420-X.
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Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole.用甲硝唑治疗艰难梭菌结肠炎后效果相对较差。
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Clostridium difficile--associated diarrhea.艰难梭菌相关性腹泻
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