Bozcuk Hakan, Artac Mehmet, Kara Arzu, Ozdogan Mustafa, Sualp Yeliz, Topcu Zekiye, Karaagacli Ayse, Yildiz Mustafa, Savas Burhan
Akdeniz University Medical Faculty, Dept. of Medical Oncology, Antalya, Turkey.
Med Sci Monit. 2006 May;12(5):CR200-5.
Adjuvant chemotherapy is associated with poor quality of life (qol) in breast cancer patients. We tested the effect of listening to music during chemotherapy on quality of life in these patients.
MATERIAL/METHODS: We tested in a prospective cohort the changes in qol scores as assessed by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), and the influence of listening to non-preferred music at the chemotherapy unit on these parameters in a mixed linear model by repeated measures analysis of variance (RMANOVA).
For the whole cohort, musical intervention was not associated with a change in any dimension of quality of life. However; the music effect significantly interacted with patient age; patients > 45 years old had improved insomnia and appetite loss scores after musical intervention (F = 6.76, P = 0.019 and F = 11.22, P = 0.004, respectively).
Our results show that brief, non-preferred music exposure at the time of chemotherapy administration does not improve quality of life in patients with early breast cancer. Nonetheless, there is still a possibility that a subgroup will benefit from this approach as suggested by the interaction of the music effect with patient age.
辅助化疗与乳腺癌患者的生活质量差有关。我们测试了化疗期间听音乐对这些患者生活质量的影响。
材料/方法：我们在前瞻性队列中测试了由欧洲癌症研究与治疗组织生活质量问卷（EORTC QLQ-C30）评估的生活质量评分变化，以及在化疗科室听不喜欢的音乐对这些参数的影响，采用重复测量方差分析（RMANOVA）的混合线性模型。
对于整个队列，音乐干预与生活质量的任何维度变化均无关联。然而，音乐效果与患者年龄存在显著交互作用；45岁以上患者在音乐干预后失眠和食欲减退评分有所改善（F分别为6.76，P = 0.019和F = 11.22，P = 0.004）。
我们的结果表明，化疗给药时短暂接触不喜欢的音乐并不能改善早期乳腺癌患者的生活质量。尽管如此，正如音乐效果与患者年龄的交互作用所表明的，仍有一个亚组可能从这种方法中受益。
