Biing J T, Liu H S, Yang Y F, Tyan H S, Yin C S
Department of Obstetrics and Gynecology, Tri-Service General Hospital, Taipei, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1991 Dec;48(6):469-76.
Small cell carcinomas are rare in cervical cancers and appear to be a heterogeneous group of tumors. Neuroendocrine carcinoma of the cervix, one subtype of small cell carcinomas of the cervix, can be identified by characteristic light and electron microscopic criteria. Two cases of neuroendocrine carcinomas associated with squamous cell carcinomas of the uterine cervix are reported in which electron microscopic studies were performed. The presence of small dense-core membrane-bound granules (120 to 160 nm) in cytoplasmic process under electron microscopic observation confirmed the diagnosis of neuroendocrine carcinoma of the cervix. The coexistence of electron dense-core membrane-bound granules, abundant tonofibrils, and desmosomes within the cancer cells, suggests that these tumors may have derived from the multipotential precursor cells with neuroendocrine and squamous differentiation. Because neuroendocrine carcinomas appear to have the highest incidence of recurrence and the poorest prognosis, it is necessary to distinguish these neoplasms from squamous cell carcinomas of the cervix. Literature about neuroendocrine carcinomas of the cervix is also reviewed.
小细胞癌在宫颈癌中较为罕见，似乎是一组异质性肿瘤。宫颈神经内分泌癌是宫颈小细胞癌的一种亚型，可通过特征性的光镜和电镜标准来识别。本文报道了2例与子宫颈鳞状细胞癌相关的神经内分泌癌病例，并对其进行了电镜研究。电镜观察发现细胞质突起中存在小的、致密核心的膜结合颗粒（120至160纳米），证实了宫颈神经内分泌癌的诊断。癌细胞内电子致密核心的膜结合颗粒、丰富的张力原纤维和桥粒并存，提示这些肿瘤可能起源于具有神经内分泌和鳞状分化的多潜能前体细胞。由于神经内分泌癌似乎具有最高的复发率和最差的预后，因此有必要将这些肿瘤与宫颈鳞状细胞癌区分开来。本文还对宫颈神经内分泌癌的相关文献进行了综述。
