Groben P, Reddick R, Askin F
Department of Pathology, School of Medicine, University of North Carolina, Chapel Hill 27514.
Int J Gynecol Pathol. 1985;4(1):42-57. doi: 10.1097/00004347-198501000-00004.
Small cell carcinoma of the cervix is a term used to describe several entities including cervical carcinoid, "oat cell" carcinoma, reserve cell carcinoma, and poorly differentiated nonkeratinizing squamous cell carcinoma. The light microscopic, ultrastructural, and clinical features of seven small cell cervical carcinomas are presented in this report. Five tumors in our report were diagnosed as small cell anaplastic or oat cell carcinoma by light microscopy. This diagnosis was associated with a poor prognosis, and four of these patients were dead of disease within 24 months. The ultrastructural features of these tumors were similar, but neurosecretory granules were demonstrable in only three of the five cases. Evidence of glandular differentiation was present in one of the five cases, and dual differentiation, i.e., neuroendocrine and squamous, was noted in another. The similarities between pulmonary small cell carcinoma and these cervical lesions are discussed and the literature is reviewed. Also included in the study is a well-differentiated neuroendocrine lesion, a carcinoid that behaved in an aggressive fashion. The final case was a carcinoma putatively derived from reserve cells. The features that help make the diagnosis of reserve cell carcinoma and that distinguish this lesion from other small cell carcinomas are presented.
宫颈小细胞癌是一个用于描述多种病变的术语，包括宫颈类癌、“燕麦细胞”癌、储备细胞癌以及低分化非角化鳞状细胞癌。本报告展示了7例宫颈小细胞癌的光镜、超微结构及临床特征。我们报告中的5例肿瘤经光镜诊断为小细胞间变性或燕麦细胞癌。这一诊断与预后不良相关，其中4例患者在24个月内死于该疾病。这些肿瘤的超微结构特征相似，但仅5例中的3例可显示神经分泌颗粒。5例中的1例有腺性分化证据，另1例则表现为神经内分泌和鳞状细胞的双重分化。本文讨论了肺小细胞癌与这些宫颈病变之间的相似性并回顾了相关文献。该研究还纳入了1例分化良好的神经内分泌病变，即1例具有侵袭性表现的类癌。最后1例为推测起源于储备细胞的癌。文中介绍了有助于诊断储备细胞癌以及将该病变与其他小细胞癌相鉴别的特征。
