Barrett R J, Davos I, Leuchter R S, Lagasse L D
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.
Cancer. 1987 Nov 1;60(9):2325-30. doi: 10.1002/1097-0142(19871101)60:9<2325::aid-cncr2820600935>3.0.co;2-g.
Neuroendocrine or argyrophil cell carcinoma of the cervix has recently been accepted as a distinct clinical-pathological entity. The histologic pattern of these carcinomas is usually poorly differentiated or undifferentiated. Twenty patients with a histologic diagnosis of small cell carcinoma, undifferentiated carcinoma, poorly differentiated adenocarcinoma, or poorly differentiated, adenosquamous carcinoma of the cervix were evaluated for neuroendocrine features. The results of studies to detect neurosecretory granules were positive in seven of the 20 cases. Not only small cell carcinomas, but also tumors classified as undifferentiated carcinoma and poorly differentiated, adenosquamous carcinoma contained cytoplasmic granules consistent with neuroendocrine carcinoma of the cervix. The prognosis for survival appears poorer for patients having tumors with neurosecretory granules after controlling for stage and histologic grade of the neoplasm.
宫颈神经内分泌癌或嗜银细胞癌最近已被确认为一种独特的临床病理实体。这些癌的组织学模式通常为低分化或未分化。对20例经组织学诊断为宫颈小细胞癌、未分化癌、低分化腺癌或低分化腺鳞癌的患者进行了神经内分泌特征评估。检测神经分泌颗粒的研究结果在20例中有7例呈阳性。不仅小细胞癌，而且分类为未分化癌和低分化腺鳞癌的肿瘤均含有与宫颈神经内分泌癌一致的细胞质颗粒。在控制肿瘤分期和组织学分级后，有神经分泌颗粒肿瘤的患者生存预后似乎更差。
