来自马达加斯加红色海藻霍氏波蒂藻的DNA甲基转移酶抑制性卤代单萜。
DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii.
作者信息
Andrianasolo Eric H, France Dennis, Cornell-Kennon Susan, Gerwick William H
机构信息
College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.
出版信息
J Nat Prod. 2006 Apr;69(4):576-9. doi: 10.1021/np0503956.
Three new halogenated monoterpenes, 2, 3, and 4, along with the known compounds halomon (1) and two analogues, 5 and 6, were isolated from the Madagascar red marine alga Portieria hornemannii. The structures of all three new compounds were determined by NMR spectroscopy in combination with mass spectrometric data analysis. Two of these monoterpenes (1 and 2) were low micromolar inhibitors of DNA methyl transferase-1.
从马达加斯加红色海藻霍氏波蒂埃藻（Portieria hornemannii）中分离出三种新的卤代单萜化合物2、3和4，以及已知化合物卤代霉素（1）和两种类似物5和6。通过核磁共振光谱结合质谱数据分析确定了所有三种新化合物的结构。其中两种单萜化合物（1和2）是DNA甲基转移酶-1的低微摩尔抑制剂。
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