Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa.
Phytochemistry. 2011 Jun;72(8):769-72. doi: 10.1016/j.phytochem.2011.02.003. Epub 2011 Mar 9.
Five known (1, 2, 4, 6 and 7) halogenated monoterpenes together with 1Z,3R∗,4S∗,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene (3) and (3R∗,4S∗)-3,4,6,7-tetrachloro-3,7-dimethyl-octen-1-ene (5) were isolated from the red macroalga Plocamium suhrii and their structures deduced from their spectroscopic data. The seven compounds from P. suhrii together with five related compounds from Plocamium cornutum have been evaluated for their cytotoxic effects on an esophageal cancer cell line (WHCO1). Compounds 1-6 showed greater cytotoxicity in this assay as compared to the known anticancer drug cisplatin.
从红色大型海藻 Plocamium suhrii 中分离得到了五种已知的（1,2,4,6 和 7）卤代单萜，以及 1Z,3R∗,4S∗,5E,7Z）-1-溴-3,4,8-三氯-7-（二氯甲基）-3-甲基-1,5,7-辛三烯（3）和（3R∗,4S∗）-3,4,6,7-四氯-3,7-二甲基-辛烯-1-烯（5），并根据其光谱数据推断出它们的结构。从 P. suhrii 中分离得到的这七种化合物以及从 Plocamium cornutum 中分离得到的五种相关化合物，已针对其对食管癌细胞系（WHCO1）的细胞毒性作用进行了评估。与已知的抗癌药物顺铂相比，化合物 1-6 在该试验中表现出更强的细胞毒性。
