Knott Michael G, Mkwananzi Henry, Arendse Catherine E, Hendricks Denver T, Bolton John J, Beukes Denzil R
Faculty of Pharmacy, Rhodes University, Artillery Road, Grahamstown, 6140, South Africa.
Phytochemistry. 2005 May;66(10):1108-12. doi: 10.1016/j.phytochem.2005.03.029.
Three new polyhalogenated monoterpenes, plocoralides A-C (1-3) along with three known compounds (4-6) have been isolated from the organic extract of the red alga P. corallorhiza. Structures of the new compounds were characterized as 4,8-dibromo-1,1-dichloro-3,7-dimethyl-2E,6E-octadiene (1), 4,6-dibromo-1,1-dichloro-3,7-dimethyl-2E,7-octadiene (2) and 4,8-dibromo-1,1,7-trichloro-3,7-dimethyl-2E,5Z-octadiene (3) on the basis of one- and two-dimensional NMR spectroscopic data and MS analyses. Compounds 2-6 show moderate cytotoxicity toward esophageal cancer cells.
从红藻珊瑚根藻的有机提取物中分离出三种新的多卤代单萜，即珊瑚藻内酯A - C（1 - 3）以及三种已知化合物（4 - 6）。根据一维和二维核磁共振光谱数据以及质谱分析，新化合物的结构被表征为4,8 - 二溴 - 1,1 - 二氯 - 3,7 - 二甲基 - 2E,6E - 辛二烯（1）、4,6 - 二溴 - 1,1 - 二氯 - 3,7 - 二甲基 - 2E,7 - 辛二烯（2）和4,8 - 二溴 - 1,1,7 - 三氯 - 3,7 - 二甲基 - 2E,5Z - 辛二烯（3）。化合物2 - 6对食管癌细胞显示出中等程度的细胞毒性。
