Altaicalarins A-D，来自高山橐吾的细胞毒双环倍半萜。
Altaicalarins A-D, cytotoxic bisabolane sesquiterpenes from Ligularia altaica.
机构信息
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, People's Republic of China.
出版信息
J Nat Prod. 2010 Feb 26;73(2):139-42. doi: 10.1021/np900489h.
Four new bisabolane sesquiterpenes, altaicalarins A-D (1-4), and three known analogues (5-7) were isolated from the roots and rhizomes of Ligularia altaica. The structures were elucidated by spectroscopic methods including 2D NMR techniques, and the structure of 1 was confirmed by single-crystal X-ray diffraction. The isolated compounds were also evaluated for cytotoxic activity against human lung carcinoma (A-549), human breast adenocarcinoma (MCF-7), epidermoid carcinoma of the nasopharynx (KB), and vincristine-resistant nasopharyngeal (KBVIN) cell lines, and 1 was found to show significant cytotoxicity, with EC(50) values of 3.4, 0.8, 1.0, and 0.9 microg/mL, respectively.
从阿尔泰狗舌草的根和根茎中分离得到了四个新的半日花烷倍半萜类化合物， altaicalarins A-D（1-4），以及三个已知类似物（5-7）。通过包括二维 NMR 技术在内的光谱方法阐明了结构，并且通过单晶 X 射线衍射确定了 1 的结构。还评估了分离得到的化合物对人肺癌（A-549）、人乳腺癌（MCF-7）、鼻咽表皮样癌（KB）和长春新碱耐药鼻咽（KBVIN）细胞系的细胞毒性活性，发现 1 表现出显著的细胞毒性，EC(50) 值分别为 3.4、0.8、1.0 和 0.9 μg/mL。
Zotero 插件