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盘状红斑狼疮伴发的肉芽肿性唇炎并采用甲氨蝶呤治疗：病例报告

Cheilitis granulomatosa associated with lupus erythematosus discoid and treated with methotrexate: report of a case.

作者信息

Nazzaro Gianluca, Muratori Simona, Carrera Carlo Giovanni, Coggi Antonella, Gianotti Raffaele

机构信息

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, IT.

出版信息

An Bras Dermatol. 2015 May-Jun;90(3 Suppl 1):200-2. doi: 10.1590/abd1806-4841.20153762.

DOI:10.1590/abd1806-4841.20153762
PMID:26312716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4540550/
Abstract

We present the rare case of a 47-year-old patient, suffering from cheilitis granulomatosa and lupus erythematosus discoid: this association is really exceptional because only once reported in English literature. In addition, the treatment of cheilitis granulomatosa is a challenge for the dermatologist: the gold standard, represented by steroids, is in fact designed as a short-time option. Our report confirms the good efficacy of methotrexate as a steroid-sparing agent.

摘要

我们报告了一例罕见病例，患者为47岁，患有肉芽肿性唇炎和盘状红斑狼疮：这种关联非常罕见，因为在英文文献中仅被报道过一次。此外，肉芽肿性唇炎的治疗对皮肤科医生来说是一项挑战：以类固醇为代表的金标准实际上只是一种短期选择。我们的报告证实了甲氨蝶呤作为一种类固醇节约剂具有良好疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97c3/4540550/65d5e0816d0e/abd-90-03-s1-0200-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97c3/4540550/c0511857beee/abd-90-03-s1-0200-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97c3/4540550/f8c3917c5a3b/abd-90-03-s1-0200-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97c3/4540550/65d5e0816d0e/abd-90-03-s1-0200-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97c3/4540550/c0511857beee/abd-90-03-s1-0200-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97c3/4540550/f8c3917c5a3b/abd-90-03-s1-0200-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97c3/4540550/65d5e0816d0e/abd-90-03-s1-0200-g03.jpg

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本文引用的文献

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The Melkersson-Rosenthal syndrome: a retrospective study of biopsied cases.梅尔基奥森-罗森塔尔综合征：活检病例的回顾性研究。
J Neurol. 2013 Jan;260(1):138-43. doi: 10.1007/s00415-012-6603-6. Epub 2012 Jul 27.
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Successful treatment of cheilitis granulomatosa with intralesional injection of triamcinolone.曲安奈德皮损内注射成功治疗肉芽肿性唇炎
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Cheilitis granulomatosa: overview of 13 patients with long-term follow-up--results of management.肉芽肿性唇炎：13例长期随访患者的概述——治疗结果
Int J Dermatol. 2002 Apr;41(4):225-9. doi: 10.1046/j.1365-4362.2002.01466.x.
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Cheilitis granulomatosa.肉芽肿性唇炎
J Eur Acad Dermatol Venereol. 2001 Nov;15(6):519-23. doi: 10.1046/j.1468-3083.2001.00353.x.
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Oral Crohn disease: clinical characteristics and long-term follow-up of 9 cases.
Arch Dermatol. 1999 Apr;135(4):439-42. doi: 10.1001/archderm.135.4.439.
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Association between cheilitis granulomatosa and Crohn's disease.肉芽肿性唇炎与克罗恩病之间的关联。
J Am Acad Dermatol. 1993 May;28(5 Pt 1):801. doi: 10.1016/s0190-9622(09)80285-5.