Kulkarni A, Lee C A, Griffeon A, Kadir R A
Department of Obstetrics and Gynaecology, Royal Free Hospital, London, UK.
Haemophilia. 2006 May;12(3):248-52. doi: 10.1111/j.1365-2516.2006.01219.x.
To review menstrual problems in women with congenital FVII deficiency and to study their effect on the quality of life during menstruation in women with congenital FVII deficiency.
14 women with congenital factor VII deficiency registered with the Haemophilia Centre at the Royal Free Hospital were interviewed and their case notes reviewed. All women completed Pictorial Blood assessment Chart (PBAC) for assessment of menstrual blood loss and a quality of life questionnaire during menstruation. Similar questionnaire and PBAC was completed by an age matched healthy control group of 23 women.
Median age of study group was 35 yrs and of control group 34 yrs. Median FVII level of the study group was 31.5 IU/dL Two women had severe FVII deficiency (FVII level < 10 IU/dL) and 12 women had mild-moderate FVII deficiency. 57% women (8/14) from study group had menorrhagia (PBAC score > 100) compared with 17% (4/23) women from the control group. Six women (43%) from the study group were diagnosed with anaemia due to heavy periods, compared to two (9%) in the control group. The quality of life scores during menstruation were significantly worse in the women with FVII deficiency, compared to controls.
Women with factor VII deficiency exhibit a spectrum of bleeding symptoms, menorrhagia being one of the commonest symptoms. This has adverse effect on their quality of life.
回顾先天性FVII缺乏症女性的月经问题，并研究其对先天性FVII缺乏症女性月经期间生活质量的影响。
对在皇家自由医院血友病中心登记的14名先天性因子VII缺乏症女性进行了访谈，并查阅了她们的病历。所有女性都完成了用于评估月经量的图片式失血评估图（PBAC）以及月经期间的生活质量问卷。23名年龄匹配的健康女性组成的对照组也完成了类似的问卷和PBAC。
研究组的中位年龄为35岁，对照组为34岁。研究组的中位FVII水平为31.5 IU/dL。两名女性患有严重的FVII缺乏症（FVII水平<10 IU/dL），12名女性患有轻度至中度FVII缺乏症。研究组中57%的女性（8/14）月经过多（PBAC评分>100），而对照组中这一比例为17%（4/23）。研究组中有6名女性（43%）因月经过多被诊断为贫血，而对照组中有两名（9%）。与对照组相比，FVII缺乏症女性月经期间的生活质量得分明显更差。
因子VII缺乏症女性表现出一系列出血症状，月经过多是最常见的症状之一。这对她们的生活质量有不利影响。
