Department of Obstetrics and Gynaecology, Haemophilia Centre, Royal Free Hospital, London, UK.
Haemophilia. 2012 May;18(3):413-20. doi: 10.1111/j.1365-2516.2011.02712.x. Epub 2011 Dec 21.
There are currently limited data on the use of endometrial ablation in the treatment of heavy menstrual bleeding (HMB) in women with inherited bleeding disorders (IBDs). A retrospective review of prospectively collected data was performed. Twelve women with IBDs who had received endometrial ablation for the treatment of HMB were identified and their records reviewed. Details of their menstrual history; quality of life (QOL) and amount of menstrual blood loss [as assessed by pictorial blood-loss assessment chart (PBAC) and haemoglobin (Hb) concentration] pre and post-ablation were collected. Twelve women were included. The median duration of follow-up post-ablation was 32 months (range, 6-76). The median duration of menstruation decreased from 11 to 0 days after treatment (P = 0.004). Median PBAC scores decreased from 1208 preop to 0 post-ablation (P = 0.002).The median Hb concentrations (10.5-13.1 g dL(-1)) and QOL scores (median, 17-54) improved significantly after endometrial ablation (P < 0.01). Endometrial ablation appears to be a safe and effective long-term treatment for HMB in women with IDBs. It significantly decreases menstrual blood loss and improves QOL.
目前，关于子宫内膜消融术在遗传性出血性疾病（IBD）妇女中治疗月经过多（HMB）的应用数据有限。我们进行了前瞻性数据的回顾性分析。确定了 12 名因 HMB 接受子宫内膜消融术治疗的 IBD 妇女，并对其病历进行了回顾。收集了她们的月经史、生活质量（QOL）和月经量（通过图片出血量评估图表（PBAC）和血红蛋白（Hb）浓度评估）的详细信息，包括术前和术后。共纳入 12 名女性。消融术后的中位随访时间为 32 个月（范围 6-76 个月）。治疗后月经持续时间中位数从 11 天缩短至 0 天（P = 0.004）。PBAC 评分中位数从术前的 1208 分降至术后的 0 分（P = 0.002）。血红蛋白浓度（10.5-13.1 g/dL(-1))和 QOL 评分（中位数 17-54）在子宫内膜消融术后显著改善（P < 0.01）。子宫内膜消融术似乎是治疗 IBD 妇女 HMB 的一种安全有效的长期治疗方法。它可显著减少月经出血量并改善 QOL。
