Lansbergen Gideon, Akhmanova Anna
MGC Department of Cell Biology, Erasmus Medical Center, 3000 DR Rotterdam, the Netherlands.
Traffic. 2006 May;7(5):499-507. doi: 10.1111/j.1600-0854.2006.00400.x.
Microtubules (MTs) are highly dynamic polymers, which control many aspects of cellular architecture. Growing MT plus ends accumulate a specific set of evolutionary conserved factors, the so-called MT plus-end-tracking proteins (+TIPs). +TIPs regulate MT dynamics and the reciprocal interactions of MTs with the cell cortex, mitotic kinetochores or different cellular organelles. Most +TIPs can directly bind to MTs, but the molecular mechanisms of their specific targeting to the growing plus ends remain poorly understood. Recent studies suggest that the members of one particular +TIP family, EB1 and its homologues, are present in all eucaryotic kingdoms, interact directly with the majority of other known plus-end-associated proteins and may be responsible for their specific accumulation at the MT tips.
微管（MTs）是高度动态的聚合物，控制着细胞结构的许多方面。生长中的微管正端积累了一组特定的进化保守因子，即所谓的微管正端追踪蛋白（+TIPs）。+TIPs调节微管动力学以及微管与细胞皮层、有丝分裂动粒或不同细胞器之间的相互作用。大多数+TIPs可以直接与微管结合，但其特异性靶向生长中的正端的分子机制仍知之甚少。最近的研究表明，一个特定的+TIP家族成员，EB1及其同源物，存在于所有真核生物界，直接与大多数其他已知的正端相关蛋白相互作用，并可能负责它们在微管尖端的特异性积累。
