Institute of Experimental Endocrinology and Oncology "G. Salvatore" (IEOS), National Research Council (CNR), Via P. Castellino 111, 80131 Naples, Italy.
Cells. 2022 Jan 21;11(3):354. doi: 10.3390/cells11030354.
The Golgi complex of mammalian cells is organized in a ribbon-like structure often closely associated with the centrosome during interphase. Conversely, the Golgi complex assumes a fragmented and dispersed configuration away from the centrosome during mitosis. The structure of the Golgi complex and the relative position to the centrosome are dynamically regulated by microtubules. Many pieces of evidence reveal that this microtubule-mediated dynamic association between the Golgi complex and centrosome is of functional significance in cell polarization and division. Here, we summarize findings indicating how the Golgi complex and the centrosome cooperate in organizing the microtubule network for the directional protein transport and centrosome positioning required for cell polarization and regulating fundamental cell division processes.
哺乳动物细胞的高尔基复合体呈带状结构，在细胞间期常与中心体密切相关。相反，在有丝分裂过程中，高尔基复合体远离中心体，呈碎片化和弥散状。高尔基复合体的结构和与中心体的相对位置受微管动态调节。大量证据表明，高尔基复合体与中心体之间这种微管介导的动态联系在细胞极化和分裂中具有重要的功能意义。在这里，我们总结了一些发现，这些发现表明高尔基复合体和中心体如何合作组织微管网络，用于定向蛋白运输和中心体定位，这是细胞极化所必需的，并且调节基本的细胞分裂过程。
