Soupene Eric, Kuypers Frans A
Children's Hospital Oakland Research Institute, Martin Luther King Jr Way, Oakland, CA 94609, USA.
Br J Haematol. 2006 May;133(4):436-8. doi: 10.1111/j.1365-2141.2006.06051.x.
The asymmetric distribution of amino-containing phospholipids in plasma membranes is essential for the function and survival of mammalian cells. Phosphatidylserine (PS) is restricted to the inner leaflet of plasma membranes by an ATP-dependent transport process. Exposure of PS on the surface of cells serves as a binding site for haemostatic factors, triggers cell-cell interaction and recognition by macrophages and phospholipases. Exposure of PS on the red cell surface plays a significant role in sickle cell pathology. We report the identification of two different isoforms of the aminophospholipid translocase, Atp8a1, or flippase, in the murine red blood cell membrane.
含氨基磷脂在质膜中的不对称分布对于哺乳动物细胞的功能和存活至关重要。磷脂酰丝氨酸（PS）通过ATP依赖的转运过程被限制在质膜的内小叶。PS在细胞表面的暴露作为止血因子的结合位点，触发细胞间相互作用以及巨噬细胞和磷脂酶的识别。PS在红细胞表面的暴露在镰状细胞病理学中起重要作用。我们报告了在小鼠红细胞膜中鉴定出氨基磷脂转位酶Atp8a1或翻转酶的两种不同同工型。
