Devaux P F, Zachowski A, Morrot G, Cribier S, Fellmann P, Geldwerth D, Bitbol M, Herve P
Institut de Biologie Physico-Chimique (UA 526 CNRS), Paris, France.
Biotechnol Appl Biochem. 1990 Oct;12(5):517-22.
The aminophospholipid translocase is a plasma membrane Mg2(+)-ATPase which selectively pumps the aminophospholipids (phosphatidylserine and phosphatidylethanolamine) from the outer to the inner monolayer in eukaryotic cells and is predominantly responsible for the asymmetric phospholipid distribution of the plasma membrane. Similar ATP-dependent transport of phospholipid takes place in some organelles such as chromaffin granules. On the other hand, the phospholipid flippase of rat liver endoplasmic reticulum does not require ATP and has a low lipid specificity. The biological implications of these phospholipid flippases are discussed.
氨基磷脂转位酶是一种质膜Mg2(+)-ATP酶，它在真核细胞中选择性地将氨基磷脂（磷脂酰丝氨酸和磷脂酰乙醇胺）从外单层泵至内单层，并且主要负责质膜的不对称磷脂分布。在一些细胞器如嗜铬颗粒中也发生类似的依赖ATP的磷脂转运。另一方面，大鼠肝脏内质网的磷脂翻转酶不需要ATP，并且脂质特异性较低。本文讨论了这些磷脂翻转酶的生物学意义。
