Malik Shahram N, Hopkins Mary, Young William B, Silberstein Stephen D
Thomas Jefferson University, Jefferson Headache Center, Philadelphia, PA 19107, USA.
Headache. 2006 May;46(5):773-80. doi: 10.1111/j.1526-4610.2006.00437.x.
The sequence and timing of taking migraine medications, whether prescription or over-the-counter, and the patient's response to their treatment, is unknown.
To describe the use of, response to, and satisfaction with acute medications for 1 migraine attack.
We performed a clinic-based survey of 127 patients at Jefferson Headache Center, Philadelphia. Adult patients who met the International Headache Society criteria for migraine with or without aura were included in the study. Patients were asked to complete a questionnaire.
Of 109 participants who met the inclusion criteria, most waited 1 hour or more after the onset of symptoms to take medication. Triptans were most commonly used as first, second, and third medications. Triptan use was associated with higher 2-hour pain-free response rates compared with other agents, whether the triptan was used as the first, second, or third medication. Patients who were treated with medications other than triptans were more likely to have pain at 2 hours (P = .36). NSAIDs had relatively low pain-free and headache relief response rates at 2 hours. Sixty-two participants (56.9%) had to treat a second time and 31 (28.4%) had to treat a third time. Some participants (17.6%) had headache recurrence within 24 hours after becoming headache free following initial medication and some (23.5%) had recurrence after becoming headache free following their second medication. Sixty-six percent of participants reported being very satisfied/satisfied with their initial medication and 33% were somewhat dissatisfied/dissatisfied to some degree. Even though most patients were satisfied with their medication, 88% reported that they would be willing to try a new antimigraine medication. Most patients (60 [55%]) preferred a long-acting agent versus a rapid-onset, short-acting agent (which was preferred by 49 [45%] patients).
Migraine patients have treatment preferences. They generally want a drug that provides complete headache relief, and they are often satisfied with the current treatment options.
偏头痛药物（无论是处方药还是非处方药）的服用顺序和时间，以及患者对治疗的反应尚不清楚。
描述针对1次偏头痛发作的急性药物的使用情况、反应及满意度。
我们在费城杰斐逊头痛中心对127名患者进行了基于诊所的调查。符合国际头痛协会有或无先兆偏头痛标准的成年患者纳入研究。患者被要求完成一份问卷。
在109名符合纳入标准的参与者中，大多数人在症状发作后1小时或更长时间才服药。曲坦类药物最常被用作第一、第二和第三种药物。与其他药物相比，无论曲坦类药物是用作第一种、第二种还是第三种药物，使用曲坦类药物的2小时无痛反应率更高。使用非曲坦类药物治疗的患者在2小时时更有可能仍有疼痛（P = 0.36）。非甾体抗炎药在2小时时的无痛和头痛缓解反应率相对较低。62名参与者（56.9%）不得不进行第二次治疗，31名（28.4%）不得不进行第三次治疗。一些参与者（17.6%）在首次服药后头痛消失24小时内出现头痛复发，一些（23.5%）在第二次服药后头痛消失后出现复发。66%的参与者报告对其初始药物非常满意/满意，33%的人在某种程度上不满意/不满意。尽管大多数患者对其药物满意，但88%的人报告他们愿意尝试一种新的抗偏头痛药物。大多数患者（60名[55%]）更喜欢长效药物，而不是起效快的短效药物（49名[45%]患者更喜欢短效药物）。
偏头痛患者有治疗偏好。他们通常想要一种能完全缓解头痛的药物，并且他们通常对当前的治疗选择感到满意。
