[Effects of inosine injection in expression of myosin heavy chain in intrafusal and extrafusal myofibers in soleus muscle of tail-suspended rats].

AIM

To study the effects of inosine on myosin heavy chain (MHC) activity in rats soleus muscle after tail-suspension.

METHODS

Weightlessness was simulated by tail-suspension of rats. Using immunohistochemistry technique, changes of expression of MHC in intrafusal and extrafusal fibers in soleus muscle were detected.

RESULTS

Expression of fast MHC in intrafusal and extrafusal fibers in soleus muscle increased after 14 d of simulated weightlessness, whereas in tail-suspended rats given inosine, the expression of fast MHC was not detected.

CONCLUSION

Inosine could counteract the changes in expression of MHC in intrafusal and extrafusal fibers of rats soleus under simulated weightless situation.