Cimmer Csongor, Szendi István, Csifcsák Gábor, Szekeres György, Ambrus Kovács Zoltán, Somogyi István, Benedek György, Janka Zoltán, Kéri Szabolcs
University of Szeged, Department of Psychiatry, Szeged, Hungary.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Sep 30;30(7):1225-30. doi: 10.1016/j.pnpbp.2006.03.021. Epub 2006 Apr 27.
This study was designed to investigate the relationship between abnormal neurological signs, visual contrast sensitivity, and the deficit syndrome of schizophrenia. Visual contrast sensitivity for counterphase-modulated low spatial frequency gratings was measured in 32 non-deficit and 12 deficit schizophrenia patients and 20 healthy controls subjects. Abnormal neurological signs were evaluated with the Neurological Evaluation Scale (NES). Compared with the controls, patients with schizophrenia displayed impaired visual contrast sensitivity, which was associated with sensory integration deficits, as measured with the NES. The deficit syndrome was predicted by negative symptoms and sensory integration deficits. These results suggest that early-stage perceptual dysfunctions, which may reflect the abnormality of precortical magnocellular visual pathways, are related to a specific group of abnormal neurological signs.
本研究旨在调查异常神经体征、视觉对比敏感度与精神分裂症缺陷综合征之间的关系。对32名非缺陷型和12名缺陷型精神分裂症患者以及20名健康对照者测量了对反相调制低空间频率光栅的视觉对比敏感度。使用神经评估量表（NES）评估异常神经体征。与对照组相比，精神分裂症患者表现出视觉对比敏感度受损，这与通过NES测量的感觉整合缺陷有关。缺陷综合征可由阴性症状和感觉整合缺陷预测。这些结果表明，可能反映皮质前大细胞视觉通路异常的早期感知功能障碍与一组特定的异常神经体征有关。
