Khosravani Neda, Goodarzi Mohammad Ali
Department of Clinical Psychology, College of Education and Psychology, Shiraz University, Shiraz, Iran.
Vision Res. 2013 Dec 18;93:49-53. doi: 10.1016/j.visres.2013.10.007. Epub 2013 Oct 16.
There are pieces of evidence indicating that visual deficits in patients with schizophrenia can be attributed to a deficiency in the magnocellular portion of the early visual system. The main objective of this study was to investigate the neurological dysfunction of the magnocellular pathway in patients with schizophrenia using the frequency doubling technology perimetry (FDT). The FDT has been developed based on particular neural magnocellular characteristics and can examine the magnocellular dysfunction hypothesis in schizophrenia. Twenty patients with schizophrenia (12 males and 8 females) and 20 normal subjects (10 males and 10 females) participated in this study. The spatial frequency doubling task was presented via the Humphrey perimetry instrument in order to examine the magnocellular pathway of the participants. Patients with schizophrenia showed less visual field sensitivity than normal controls and their standardized age cohort in both eyes (p<0.001). The results indicated impaired visual field sensitivity deficits in patients with schizophrenia that can be attributed to a deficit in the magnocellular neural pathways. This Magnocellular pathway defect may provide a physiological base to explain some of the deficits caused by schizophrenia such as cognitive deficits.
有证据表明，精神分裂症患者的视觉缺陷可归因于早期视觉系统大细胞部分的功能不足。本研究的主要目的是使用频率加倍技术视野检查法（FDT）来研究精神分裂症患者大细胞通路的神经功能障碍。FDT是基于特定的神经大细胞特征开发的，可用于检验精神分裂症中的大细胞功能障碍假说。20名精神分裂症患者（12名男性和8名女性）和20名正常受试者（10名男性和10名女性）参与了本研究。通过汉弗莱视野计呈现空间频率加倍任务，以检查参与者的大细胞通路。精神分裂症患者双眼的视野敏感度低于正常对照组及其标准化年龄队列（p<0.001）。结果表明，精神分裂症患者存在视野敏感度缺陷，这可归因于大细胞神经通路的功能不足。这种大细胞通路缺陷可能为解释精神分裂症导致的一些缺陷（如认知缺陷）提供生理基础。
