Saia Francesco, Schaar Johannes, Regar Evelyn, Rodriguez Gaston, De Feyter Pim J, Mastik Frits, Marzocchi Antonio, Marrozzini Cinzia, Ortolani Paolo, Palmerini Tullio, Branzi Angelo, van der Steen Antonius F W, Serruys Patrick W
Department of Interventional Cardiology, Erasmus Medical Centre, Thoraxcentre, Rotterdam, The Netherlands.
J Cardiovasc Med (Hagerstown). 2006 Jan;7(1):21-8. doi: 10.2459/01.JCM.0000199783.56642.39.
Rupture of a vulnerable plaque is the main cause of acute coronary syndromes and myocardial infarction. The features of rupture-prone atherosclerotic plaques have been previously described by pathologists. However, identification of vulnerable plaques in vivo is essential to study their natural history and to evaluate potential treatment modalities. Coronary angiography is the gold standard for the diagnosis of coronary artery disease, but it is unable to distinguish between stable and unstable plaques and to accurately predict future cardiac events. This current perspective describes the recently developed invasive imaging techniques to detect atherosclerotic vulnerable plaques in the coronary tree.
易损斑块破裂是急性冠状动脉综合征和心肌梗死的主要原因。病理学家此前已描述了易破裂动脉粥样硬化斑块的特征。然而，在体内识别易损斑块对于研究其自然病史和评估潜在治疗方式至关重要。冠状动脉造影是诊断冠状动脉疾病的金标准，但它无法区分稳定斑块和不稳定斑块，也无法准确预测未来的心脏事件。本综述描述了最近开发的用于检测冠状动脉树中动脉粥样硬化易损斑块的侵入性成像技术。
