Noh Gyu-Jeong, Kim Kye-Min, Jeong Yong-Bo, Jeong Seong-Wook, Yoon Hee-Suk, Jeong Sung-Moon, Kang Sung-Hong, Linares Olinto, Kern Steven E
Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Anesthesiology. 2006 May;104(5):921-32. doi: 10.1097/00000542-200605000-00006.
The aim of this study was to investigate the independent effect of remifentanil on the approximate entropy (ApEn) in frontoparietal montages. The authors investigated which montages were relevant to assess the remifentanil effect on the electroencephalogram. Spectral edge frequency and the canonical univariate parameter were used as comparators.
Twenty-eight healthy volunteers were enrolled. With recording of the electroencephalogram at the F3, F4, Cz, P3, and P4 montages, remifentanil was infused at the rate of 1-8 mug . kg . min for 15-20 min. The relation between remifentanil concentration and the electroencephalographic parameters were tested by Spearman correlation. Signal-to-noise ratio, artifact robustness, coefficient of variation of the median baseline and maximal electroencephalographic effects, and ratio of average maximal electroencephalographic effect to interindividual baseline variability were measured. The performance of ApEn as an index of remifentanil effect site concentrations was tested by prediction probability.
Approximate entropy showed significant correlation (R = -0.6465, P < 0.0001) with remifentanil concentration. It provided comparable signal-to-noise ratio, artifact robustness, and ratio of average maximal electroencephalographic effect to interindividual baseline variability to 95% spectral edge frequency. The coefficients of variation of the median baseline and maximal electroencephalo graphic effects were smallest in ApEn. Parietal montages showed higher ratios of average maximal electroencephalographic effect to interindividual baseline variability for all electroencephalographic parameters and lower coefficients of variation of the baseline values for ApEn and 95% spectral edge frequency than frontal montages. The prediction probability of ApEn was 0.7730.
Approximate entropy derived from a parietal montage is appropriate for the assessment of the remifentanil effect on the electroencephalogram.
本研究旨在探讨瑞芬太尼对额顶导联近似熵（ApEn）的独立影响。作者研究了哪些导联与评估瑞芬太尼对脑电图的影响相关。频谱边缘频率和典型单变量参数用作对照。
招募28名健康志愿者。在记录F3、F4、Cz、P3和P4导联脑电图的同时，以1 - 8μg·kg·min的速率输注瑞芬太尼15 - 20分钟。通过Spearman相关性检验瑞芬太尼浓度与脑电图参数之间的关系。测量信噪比、伪迹稳健性、中位基线和最大脑电图效应的变异系数，以及平均最大脑电图效应与个体间基线变异性的比值。通过预测概率检验ApEn作为瑞芬太尼效应部位浓度指标的性能。
近似熵与瑞芬太尼浓度呈显著相关性（R = -0.6465，P < 0.0001）。它提供了与95%频谱边缘频率相当的信噪比、伪迹稳健性以及平均最大脑电图效应与个体间基线变异性的比值。ApEn的中位基线和最大脑电图效应的变异系数最小。对于所有脑电图参数，顶叶导联的平均最大脑电图效应与个体间基线变异性的比值高于额叶导联，且ApEn和95%频谱边缘频率的基线值变异系数低于额叶导联。ApEn的预测概率为0.7730。
源自顶叶导联的近似熵适用于评估瑞芬太尼对脑电图的影响。
