Randi Giorgia, Naldi Luigi, Gallus Silvano, Di Landro Anna, La Vecchia Carlo
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
J Invest Dermatol. 2006 Sep;126(9):2106-10. doi: 10.1038/sj.jid.5700334. Epub 2006 Apr 27.
The risk of cutaneous malignant melanoma (CMM) is strongly associated with total number of nevi. Scanty information is available on the association between CMM at a specific anatomical site and number of nevi at the same site. We analyzed data from a case-control study conducted in Italy between 1992 and 1994, on 542 cases of CMM and 538 hospital controls. Cases and controls were examined by trained dermatologists who counted the number of melanocytic nevi. We derived multivariate odds ratios (ORs) and 95% confidence intervals (95% CIs) of site-specific risk of CMM for high versus low number of nevi at the corresponding site. The ORs of CMM for the highest versus the lowest tertile of number of nevi at the corresponding site was 1.4 (95% CIs: 0.7-2.8) at face and neck, 2.3 (95% CIs: 1.1-4.9) at anterior trunk, 4.9 (95% CIs: 2.9-8.4) at posterior trunk, 2.9 (95% CIs: 1.2-6.6) at upper limbs and 5.0 (95% CIs: 2.9-8.5) at lower limbs. In a case-case analysis, comparing CMM cases at a specific site and CMM cases at all other sites, the only excess risk was found for the posterior trunk, the ORs being 2.1 (95% CIs: 1.2-3.6) for the highest versus the lowest tertile of number of nevi. Our data do not support the hypothesis of a specific effect of nevi at each single anatomical site.
皮肤恶性黑色素瘤（CMM）的风险与痣的总数密切相关。关于特定解剖部位的CMM与同一部位痣的数量之间的关联，目前可用信息较少。我们分析了1992年至1994年在意大利进行的一项病例对照研究的数据，该研究涉及542例CMM病例和538例医院对照。由训练有素的皮肤科医生对病例和对照进行检查，统计黑素细胞痣的数量。我们得出了相应部位痣数量高与低时CMM部位特异性风险的多变量优势比（OR）和95%置信区间（95%CI）。相应部位痣数量最高三分位数与最低三分位数相比，面部和颈部CMM的OR为1.4（95%CI：0.7 - 2.8），前躯干为2.3（95%CI：1.1 - 4.9），后躯干为4.9（95%CI：2.9 - 8.4），上肢为2.9（95%CI：1.2 - 6.6），下肢为5.0（95%CI：2.9 - 8.5）。在病例 - 病例分析中，比较特定部位的CMM病例与所有其他部位的CMM病例，仅在后躯干发现了额外风险，痣数量最高三分位数与最低三分位数相比，OR为2.1（95%CI：1.2 - 3.6）。我们的数据不支持每个单一解剖部位的痣具有特定影响的假设。
