Tomalak Waldemar, Doniec Zbigniew
Zakładu Fizjopatologii Układu Oddechowego oraz Instytutu Gruźlicy i Chorób Płuc, Oddział w Rabce Zdroju.
Wiad Lek. 2006;59(1-2):61-5.
Clinical efficacy of breath actuated devices depends on value of peak inspiratory flow (PIF). Therefore the aim of our study was to assess PIF Rate (PIFR) in asthmatic children with bronchial obturation (FEV1%FVC < lower limit of normal). Thirty five children aged (average) 11.5 years participated in the study. PIFR was obtained with InCheck (Clement Clark, UK) with resistance valves for Turbuhaler, Discus, Easi Breathe and Autohaler inhalers, then peak inspiratory flow was assessed spirometrically (LungTest 1000, MES SJ, Poland). Maximal value of PIFR (PIFRmax=120 l/min) was obtained by 24 (69%) children for Easi Breathe, 3 (9%) children for Autohaler, 2 (6.5%) children for Discus, for Turbuhalera none of the children reached PIFRmax, differences in assessing PIFRmax were statistically significant (p < 0.05). However, all the children were able to generate minimal and optimal PIFR for all inhalers. There were no correlation between the degree of bronchial obstruction and PIFR values, but significant correlation was found between spirometric PIF and PIFR for different devices. All four tested inhalers can be used by children with bronchial obstruction, and the highest PIFR (as well as most frequently maximal PIFR) is obtained with Easi Breathe inhaler.
呼吸驱动装置的临床疗效取决于吸气峰流速(PIF)的值。因此,我们研究的目的是评估患有支气管阻塞(FEV1%FVC<正常下限)的哮喘儿童的PIF速率(PIFR)。35名平均年龄为11.5岁的儿童参与了该研究。使用带有用于都保、准纳器、易纳器和自动吸入器的阻力阀的InCheck(英国克莱门特·克拉克公司)获得PIFR,然后通过肺功能仪(波兰MES SJ公司的LungTest 1000)评估吸气峰流速。24名(69%)儿童使用易纳器获得了PIFR的最大值(PIFRmax = 120升/分钟),3名(9%)儿童使用自动吸入器,2名(6.5%)儿童使用准纳器,使用都保时没有儿童达到PIFRmax,评估PIFRmax的差异具有统计学意义(p<0.05)。然而,所有儿童都能够为所有吸入器产生最小和最佳的PIFR。支气管阻塞程度与PIFR值之间没有相关性,但不同装置的肺功能仪测量的PIF与PIFR之间存在显著相关性。所有四种测试的吸入器都可供支气管阻塞的儿童使用,使用易纳器可获得最高的PIFR(以及最频繁的最大PIFR)。