[The relationship between ECM1 and the angiogenesis and metastasis of laryngeal carcinoma].

OBJECTIVE

To investigate the expressions of extracellular matrix protein-1 (ECM1) in laryngeal carcinoma and their relationships with the growth, metastasis and angiogenesis of tumor.

METHOD

The immunohistochemical technique was used to detect the expressions of ECM1 and VIII factor in 33 cases of laryngeal tumors. RT-PCR technology was used to test the existence of ECM1 mRNA in both fresh laryngeal tissue and its surrounding tissue (total 5 cases).

RESULT

ECM1 is expressed in both benign and malignant laryngeal tissues, chiefly in the cellular plasma. But the expression of ECM1 (P<0.01) is significant different between benign and malignant laryngeal tumors. Their expressions are stronger in malignant tissues than in benign ones. In malignant laryngeal tissue, the expression of ECM1 is associated significantly with microvessel density (MVD) (24. 50 +/- 5.96) (Spearman's rho is 0. 505, P <0.05). ECM1 mRNA is found in both laryngeal carcinoma tissue and its surrounding tissue and it seemed no difference.

CONCLUSION

ECM1 played an important role in the growth, metastasis and angiogenesis of laryngeal carcinoma. The further investigation of ECM1 will benefit the treatment of laryngeal carcinoma and the judgement of its prognosis.