Wang Shu-fei, Xu Jin-cheng, Liang Qing-xiang
The Affiliated Shenzhen Baoan Hospital of Nanfang Medical College, Shenzhen 518101, Guangdong, China.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Apr;18(4):237-9.
To investigate the role of interleukin-18 (IL-18) and interferon-gamma (IFN-gamma) in coronary heart disease (CHD).
The levels of plasma IL-18 and IFN-gamma in 45 patients with CHD and 30 normal volunteers were determined by enzyme linked immunoadsorbent assay (ELISA). The correlation between the levels of these two cytokines and the relationship between their levels and the state of CHD were analyzed.
The plasma levels of IL-18 and IFN-gamma in patients with CHD were increased significantly when compared to those in normal controls [IL-18: (373.6+/-176.7) ng/L vs. (226.3+/-88.9) ng/L, P<0.01; IFN-gamma: (1.769+/-0.087) ng/L vs. (0.087+/-0.038) ng/L, P<0.01]. The two cytokines were positively correlated significantly (r=0.788, P<0.01)]. The plasma levels of IL-18 and IFN-gamma were significantly different in different states of CHD, and they increased with the aggravation of CHD respectively (all P<0.01). Moreover, the plasma levels of IL-18 and IFN-gamma in patients complicated with heart failure (HF) were higher than those not complicated with HF, respectively (all P<0.01).
The findings suggest that IL-18 and IFN-gamma may participate in the pathogenesis and progression of CHD. The plasma levels of two cytokines may be used as parameters of estimation the morbid state of CHD.
探讨白细胞介素-18（IL-18）和干扰素-γ（IFN-γ）在冠心病（CHD）中的作用。
采用酶联免疫吸附测定（ELISA）法测定45例冠心病患者和30名正常志愿者血浆中IL-18和IFN-γ水平。分析这两种细胞因子水平之间的相关性及其与冠心病病情的关系。
与正常对照组相比，冠心病患者血浆中IL-18和IFN-γ水平显著升高[IL-18：（373.6±176.7）ng/L对（226.3±88.9）ng/L，P<0.01；IFN-γ：（1.769±0.087）ng/L对（0.087±0.038）ng/L，P<0.01]。这两种细胞因子呈显著正相关（r=0.788，P<0.01）。不同冠心病病情状态下，血浆中IL-18和IFN-γ水平有显著差异，且均随冠心病病情加重而升高（均P<0.01）。此外，合并心力衰竭（HF）患者血浆中IL-18和IFN-γ水平分别高于未合并HF患者（均P<0.01）。
研究结果表明，IL-18和IFN-γ可能参与冠心病的发病机制和病情进展。这两种细胞因子的血浆水平可作为评估冠心病病情的指标。
