Yilmaz Taner, Ceylan Mehmet, Akyön Yakut, Ozçakýr Olcay, Gürsel Bülent
Department of Otolaryngology-Head and Neck Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Otolaryngol Head Neck Surg. 2006 May;134(5):772-7. doi: 10.1016/j.otohns.2006.02.002.
Evaluate possible role of Helicobacter Pylori in pathogenesis of otitis media with effusion (OME).
Randomized controlled trial, tertiary referral center.
Middle ear fluid was aspirated, a biopsy was taken from the promontorium of 22 children with OME.
A small biopsy was taken from the promontorium of 20 children with normal otologic findings. For both groups, 5 mm deep tissue specimens were obtained from tonsil and adenoid.
H pylori presence in the middle ear, the tonsillar and adenoid tissues by culture and PCR was significantly more frequent in the study group compared to the control group (P<0.05).
This study is the first to grow H pylori in middle ear in OME. Significantly increased colonization by H pylori of the middle ear, and tonsillar and adenoid tissue in patients with OME indicates that the bacteria might be involved in the pathogenesis of OME.
A-1b.
评估幽门螺杆菌在分泌性中耳炎（OME）发病机制中的可能作用。
随机对照试验，三级转诊中心。
对22例OME患儿的中耳积液进行抽吸，并从鼓岬取活检组织。
对20例耳科检查结果正常的儿童从鼓岬取少量活检组织。两组均从扁桃体和腺样体获取5毫米深的组织标本。
与对照组相比，研究组通过培养和聚合酶链反应（PCR）检测发现中耳、扁桃体和腺样体组织中幽门螺杆菌的存在频率显著更高（P<0.05）。
本研究首次在OME患儿的中耳中培养出幽门螺杆菌。OME患者中耳、扁桃体和腺样体组织中幽门螺杆菌定植显著增加，表明该细菌可能参与了OME的发病机制。
A-1b。
