分泌性中耳炎：幽门螺杆菌可能发挥的作用？
Otitis media with effusion: a possible role for Helicobacter pylori?
作者信息
Fancy Tanya, Mathers Peter H, Ramadan Hassan H
机构信息
Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, WV, USA.
出版信息
Otolaryngol Head Neck Surg. 2009 Feb;140(2):256-8. doi: 10.1016/j.otohns.2008.11.023.
OBJECTIVES
To compare Helicobacter pylori prevalence rates in the nasopharynx of pediatric patients with and without otitis media with effusion (OME).
STUDY DESIGN
Prospective, controlled.
METHODS
The study group consisted of patients undergoing adenoidectomy for persistent OME. A control group of patients with no history of OME undergoing adenoidectomy was simultaneously enrolled. As a substudy, middle ear effusion samples were also analyzed for Helicobacter pylori. Polymerase chain reaction assays were run by using primers against the Helicobacter pylori gene.
RESULTS
Helicobacter pylori was detected in the adenoids of 10 of 45 study group patients, and 6 of 37 controls (P = 0.49). Thirty-two percent of middle ear aspirates were positive for Helicobacter pylori.
CONCLUSION
The current study confirms the presence of Helicobacter pylori in the nasopharynx and middle ear space, but our results do not support a role for this bacterium in the pathogenesis of otitis media with effusion.
目的
比较患有和未患有分泌性中耳炎（OME）的儿科患者鼻咽部幽门螺杆菌的感染率。
研究设计
前瞻性对照研究。
方法
研究组由因持续性OME接受腺样体切除术的患者组成。同时纳入一组无OME病史且接受腺样体切除术的对照组患者。作为一项子研究，还对中耳积液样本进行了幽门螺杆菌分析。使用针对幽门螺杆菌基因的引物进行聚合酶链反应检测。
结果
研究组45例患者中有10例在腺样体中检测到幽门螺杆菌，对照组37例中有6例（P = 0.49）。32%的中耳吸出物幽门螺杆菌检测呈阳性。
结论
本研究证实了鼻咽部和中耳腔中存在幽门螺杆菌，但我们的结果不支持该细菌在分泌性中耳炎发病机制中的作用。
Zotero 插件