Payne Richard J, Kost Karen M, Frenkiel Saul, Zeitouni Anthony G, Sejean George, Sweet Robert C, Naor Naftaly, Hernandez Lourdes, Kimoff R John
Department of Otolaryngology-Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, Canada.
Otolaryngol Head Neck Surg. 2006 May;134(5):836-42. doi: 10.1016/j.otohns.2006.01.012.
To evaluate the relationships between laryngeal inflammation assessed using the Reflux Finding Score (RFS), laryngeal sensory function, and apnea severity in patients with obstructive sleep apnea (OSA).
Endoscopic sensory testing (EST) was performed with subsequent blinded scoring from video of RFS. An RFS>7 was indicative of increased inflammatory change.
Of 34 patients evaluated, 29 had OSA (apnea-hypopnea index [AHI]>or=15 events/h) at polysomnography. Increased inflammation was present in 26/29 (90%), with changes suggestive of laryngopharyngeal reflux. There were significant correlations between: inflammation and OSA severity (eg, RFS vs AHI, r=0.57, P<0.001); inflammation and laryngeal sensory impairment (EST detection threshold and pressure required to elicit the laryngeal adductor reflex, LAR); and the degree of sensory impairment and OSA severity.
Laryngeal inflammation is prevalent among OSA patients and correlates with laryngeal sensory dysfunction, attenuation of the LAR, and apnea severity.
C-4.
评估采用反流发现评分（RFS）评估的喉部炎症、喉部感觉功能与阻塞性睡眠呼吸暂停（OSA）患者呼吸暂停严重程度之间的关系。
进行内镜感觉测试（EST），随后对RFS视频进行盲法评分。RFS>7表明炎症变化增加。
在接受评估的34例患者中，29例在多导睡眠图检查中患有OSA（呼吸暂停低通气指数[AHI]≥15次/小时）。26/29（90%）存在炎症增加，伴有提示喉咽反流的变化。炎症与OSA严重程度之间存在显著相关性（例如，RFS与AHI，r = 0.57，P<0.001）；炎症与喉部感觉障碍（EST检测阈值和引发喉内收肌反射所需压力，LAR）；以及感觉障碍程度与OSA严重程度之间存在显著相关性。
喉部炎症在OSA患者中普遍存在，且与喉部感觉功能障碍、LAR减弱及呼吸暂停严重程度相关。
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