Nyirjesy Paul, McIntosh Matthew J, Gattermeir David J, Schumacher Robert J, Steinmetz Jana I, Joffrion James L
Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Am J Obstet Gynecol. 2006 May;194(5):1277-82. doi: 10.1016/j.ajog.2005.11.006. Epub 2006 Apr 21.
The purpose of this study was to determine the effects of 3 intravaginal antibacterial treatments on vaginal lactobacilli in patients with bacterial vaginosis (BV).
Retrospective analyses were performed on Lactobacillus scores from 3 similar studies evaluating 2 2% clindamycin vaginal creams and 0.75% metronidazole gel at baseline and at 21 to 30 days in 408 patients with BV. Scores were compared using a 1-way global F test and McNemar's test.
All groups had similar mean Lactobacillus scores at baseline (P = 0.37) and at 21 to 30 days (P = .71). The 3 groups were also comparable at both visits with respect to the distributions of scores within each group. In all groups, there was significant improvement in the percentages of patients with no lactobacilli present at 21 to 30 days compared with baseline (P < .0001 for all comparisons).
Clindamycin and metronidazole promoted similar levels of restoration of vaginal lactobacilli at 21 to 30 days.
本研究旨在确定3种阴道内抗菌治疗对细菌性阴道病（BV）患者阴道乳酸杆菌的影响。
对408例BV患者在基线以及21至30天时，评估2种2%克林霉素阴道乳膏和0.75%甲硝唑凝胶的3项相似研究中的乳酸杆菌评分进行回顾性分析。使用单向全局F检验和 McNemar检验对评分进行比较。
所有组在基线时（P = 0.37）以及21至30天时（P = 0.71）的平均乳酸杆菌评分相似。在两次就诊时，3组在每组内评分分布方面也具有可比性。在所有组中，与基线相比，21至30天时无乳酸杆菌患者的百分比均有显著改善（所有比较P < 0.0001）。
在21至30天时，克林霉素和甲硝唑促进阴道乳酸杆菌恢复的水平相似。
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