Mitchell Caroline, Manhart Lisa E, Thomas Kathy, Fiedler Tina, Fredricks David N, Marrazzo Jeanne
Harborview Women's Clinic, Department of Obstetrics & Gynecology, University of Washington, Seattle, WA 98105, USA.
Infect Dis Obstet Gynecol. 2012;2012:706540. doi: 10.1155/2012/706540. Epub 2012 May 30.
Evaluate predictors of vaginal colonization with lactobacilli after treatment for bacterial vaginosis (BV).
Vaginal fluid specimens from women with BV underwent qPCR for Lactobacillus crispatus, L. jensenii, and L. iners pre- and posttreatment.
Few women with BV were colonized with L. crispatus (4/44, 9%) or L. jensenii (1/44, 2%), though all had L. iners. One month posttreatment 12/44 (27%) had L. crispatus, 12/44 (27%) L. jensenii, and 43/44 (98%) L. iners. Presence of L. jensenii posttreatment was associated with cure (Risk Ratio (RR) 1.67; 95% CI 1.09-2.56); L. crispatus showed a similar trend (RR 1.41; 95% CI 0.89-2.24, P = 0.14). Receptive oral sex was associated with 2.2-log(10) lower concentration of L. crispatus (95% CI -4.38, -.02), and digital-vaginal sex with 2.6-log(10) lower concentration (95% CI -4.87, -.33).
One month after BV treatment, few women established colonization with L. crispatus or L. jensenii. Few behaviors were associated with colonization.
评估细菌性阴道病（BV）治疗后阴道乳酸杆菌定植的预测因素。
对患有BV的女性的阴道液标本在治疗前和治疗后进行卷曲乳酸杆菌、詹氏乳酸杆菌和惰性乳酸杆菌的定量聚合酶链反应（qPCR）检测。
很少有BV女性被卷曲乳酸杆菌（4/44，9%）或詹氏乳酸杆菌（1/44，2%）定植，不过所有人都有惰性乳酸杆菌。治疗后1个月，12/44（27%）有卷曲乳酸杆菌，12/44（27%）有詹氏乳酸杆菌，43/44（98%）有惰性乳酸杆菌。治疗后詹氏乳酸杆菌的存在与治愈相关（风险比（RR）1.67；95%置信区间1.09 - 2.56）；卷曲乳酸杆菌显示出类似趋势（RR 1.41；95%置信区间0.89 - 2.24，P = 0.14）。接受口交与卷曲乳酸杆菌浓度降低2.2个对数（10）相关（95%置信区间 - 4.38， - 0.02），指交与浓度降低2.6个对数（10）相关（95%置信区间 - 4.87， - 0.33）。
BV治疗后1个月，很少有女性建立卷曲乳酸杆菌或詹氏乳酸杆菌定植。很少有行为与定植相关。
