To Meekai S, Fonseca Eduardo B, Molina Francisca S, Cacho Ana M, Nicolaides Kypros H
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, United Kingdom.
Am J Obstet Gynecol. 2006 May;194(5):1360-5. doi: 10.1016/j.ajog.2005.11.001. Epub 2006 Apr 21.
The purpose of this study was to examine the value of combining maternal characteristics and measurement of cervical length at 22 to 24 weeks in the prediction of spontaneous early preterm delivery.
Cervical length was measured by transvaginal sonography at 22 to 24 weeks in 1163 twin pregnancies attending for routine antenatal care. Logistic regression analysis was used to examine the effect of maternal demographic characteristics and cervical length on the risk of spontaneous early preterm delivery.
The rate of spontaneous delivery before 32 weeks was 6.5%. The rate of early delivery was inversely related to cervical length, and for a false-positive rate of 10%, the detection rate of early delivery was 65.3%. The respective detection rate for maternal characteristics and obstetric history was 26.4%. Logistic regression analysis demonstrated that the only significant independent predictor of spontaneous early delivery was cervical length.
In twins, the prediction of spontaneous early preterm delivery by measurement of cervical length at 22 to 24 weeks is not improved by maternal characteristics.
本研究旨在探讨结合孕妇特征及孕22至24周时宫颈长度测量值预测自发性早产的价值。
对1163例接受常规产前检查的双胎妊娠孕妇在孕22至24周时采用经阴道超声测量宫颈长度。采用逻辑回归分析来检验孕妇人口统计学特征及宫颈长度对自发性早产风险的影响。
32周前的自然分娩率为6.5%。早产率与宫颈长度呈负相关，在假阳性率为10%时，早产的检出率为65.3%。孕妇特征及产科史各自的检出率为26.4%。逻辑回归分析表明，自发性早产唯一显著的独立预测因素是宫颈长度。
对于双胎妊娠，孕22至24周时测量宫颈长度预测自发性早产，孕妇特征并不能提高预测效果。
