Clement Philippe, Saint-Blancard Patrick, Minvielle François, Le Page Pierre, Kossowski Michel
Department of Otorhinolaryngology-Head and Neck Surgery, Hôpital d'Instruction des Armées Percy, Clamart, France.
Am J Otolaryngol. 2006 May-Jun;27(3):207-10. doi: 10.1016/j.amjoto.2005.09.003.
Follicular dendritic cell sarcomas of the tonsil are very rare tumors. Only 10 cases have been published in the English-language medical literature. We present an additional case that occurred in a 27-year-old woman. She presented with a tumor of the right tonsil. Histological sections of tonsillar biopsies and tonsillectomy suggested that this tumor was a nerve sheath tumor or a malignant melanoma. Histological examination and immunohistochemical study were reviewed. The final diagnosis was follicular dendritic cell sarcoma. She underwent a transoral resection of the right oropharynx with ipsilateral selective neck dissection and postoperative irradiation. We emphasize the difficulties in diagnosing this type of tumor. The use of monoclonal specific markers is required to avoid misdiagnosis. We discuss therapeutic methods for this rare tumor for which optimal treatment has not yet been defined.
扁桃体滤泡树突状细胞肉瘤是非常罕见的肿瘤。英文医学文献中仅发表过10例。我们报告另外1例发生在一名27岁女性身上的病例。她表现为右侧扁桃体肿物。扁桃体活检和扁桃体切除的组织学切片提示该肿瘤为神经鞘瘤或恶性黑色素瘤。回顾了组织学检查和免疫组化研究。最终诊断为滤泡树突状细胞肉瘤。她接受了经口右侧口咽切除术及同侧选择性颈清扫术并术后放疗。我们强调诊断这类肿瘤存在困难。需要使用单克隆特异性标志物以避免误诊。我们讨论了这种尚未明确最佳治疗方案的罕见肿瘤的治疗方法。
