Miyairi Isao, Causey Karima T, DeVincenzo John P, Buckingham Steven C
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Pediatr Neurol. 2006 May;34(5):395-9. doi: 10.1016/j.pediatrneurol.2005.09.003.
This report presents three cases of neonatal group B streptococcal ventriculitis and assesses seven others identified by a literature review. In contrast to the well described acute manifestations of group B streptococcal meningitis, disease onset tended to be insidious with four of seven cases presenting over a period of 1 to 6 weeks and six cases presenting with nonspecific signs and symptoms without fever. Persistent protein content elevation and low glucose level in the cerebrospinal fluid was observed, indicating chronic inflammation. All patients developed obstructive hydrocephalus requiring ventriculoperitoneal shunt placement. One child died, and six of nine survivors were left with significant neurologic deficits. Physicians should be aware of this indolent but serious manifestation of group B streptococcal infection.
本报告介绍了3例新生儿B族链球菌性脑室炎病例，并对文献综述中确定的其他7例病例进行了评估。与已详细描述的B族链球菌性脑膜炎的急性表现不同，疾病发作往往较为隐匿，7例中有4例在1至6周内发病，6例表现为无发热的非特异性体征和症状。观察到脑脊液中蛋白质含量持续升高和葡萄糖水平降低，表明存在慢性炎症。所有患者均发展为梗阻性脑积水，需要进行脑室腹腔分流术。1名儿童死亡，9名幸存者中有6名留有严重神经功能缺损。医生应意识到B族链球菌感染的这种隐匿但严重的表现。
