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腰椎管狭窄症的诊断:诊断试验准确性的系统评价

Diagnosis of lumbar spinal stenosis: a systematic review of the accuracy of diagnostic tests.

作者信息

de Graaf Irene, Prak Anneloes, Bierma-Zeinstra Sita, Thomas Siep, Peul Wilco, Koes Bart

机构信息

Department of General Practice, Erasmus MC, Rotterdam, The Netherlands.

出版信息

Spine (Phila Pa 1976). 2006 May 1;31(10):1168-76. doi: 10.1097/01.brs.0000216463.32136.7b.

Abstract

STUDY DESIGN

Systematic review of diagnostic studies.

OBJECTIVE

To investigate the diagnostic performance of tests used to detect lumbar spinal stenosis.

SUMMARY OF BACKGROUND DATA

Little is known about the diagnostic accuracy of tests in detecting lumbar spinal stenosis. A systematic review will provide more insight in this topic.

METHODS

We performed a literature search in Medline (PubMed) and Embase for original diagnostic studies on lumbar spinal stenosis, in which one or more different tests were evaluated with a reference standard, and diagnostic values were reported or could be calculated. Two reviewers independently checked all abstracts and full text articles for inclusion criteria. Included articles were assessed for their quality using the Quadas tool. Study features and diagnostic values were extracted from the included studies.

RESULTS

Of the 24 articles included in this review, 15 concerned imaging tests, 7 evaluated "clinical tests," and 2 reported on other diagnostic tests. The overall quality was poor; only 5 studies scored positive on more than 50% of the quality items. Estimates of the diagnostic value of the tests differed considerably. The imaging studies showed no superior accuracy for myelography compared with CT or MRI. Overall, there is considerable variation in the clinical tests; some studies show high sensitivity, whereas others show high specificity.

CONCLUSIONS

Because of heterogeneity and overall poor quality, no firm conclusions about the diagnostic performance of the different tests can be drawn. Better-designed studies exploring the accuracy of diagnostic tests are needed to improve the diagnostic policy.

摘要

研究设计

诊断性研究的系统评价。

目的

探讨用于检测腰椎管狭窄症的检查方法的诊断效能。

背景资料总结

关于各种检查在检测腰椎管狭窄症方面的诊断准确性,人们了解甚少。系统评价将为该主题提供更多见解。

方法

我们在Medline(PubMed)和Embase数据库中进行文献检索,查找有关腰椎管狭窄症的原始诊断性研究,这些研究中使用一种或多种不同检查方法并以参考标准进行评估,且报告了或可计算出诊断值。两名审阅者独立检查所有摘要和全文文章是否符合纳入标准。使用Quadas工具评估纳入文章的质量。从纳入研究中提取研究特征和诊断值。

结果

本综述纳入的24篇文章中,15篇涉及影像学检查,7篇评估“临床检查”,2篇报告其他诊断检查。总体质量较差;只有5项研究在超过50%的质量项目上得分为阳性。各检查方法诊断值的估计差异很大。影像学研究显示,脊髓造影与CT或MRI相比,准确性并无优势。总体而言,临床检查存在很大差异;一些研究显示高敏感性,而另一些则显示高特异性。

结论

由于存在异质性且总体质量较差,无法就不同检查方法的诊断效能得出确切结论。需要设计更优的研究来探索诊断检查的准确性,以改进诊断策略。

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