Read D, Shulkes A, Fernley R, Simpson R
Department of Surgery, University of Melbourne, Austin Hospital, Victoria, Australia.
Peptides. 1991 Jul-Aug;12(4):887-92. doi: 10.1016/0196-9781(91)90152-f.
Neurotensin(6-13) has been isolated and sequenced as the major form of neurotensin-like immunoreactivity (NTLI) in a human hepatic fibrolamellar carcinoma. Circulating NTLI in the patient, especially C-terminal, was very high. In additional studies, NT(6-13) was synthesized and compared with the purified tumor NTLI by HPLC analysis and by testing stability in plasma in vitro. These methods confirmed that the tumor NTLI was identical to NT(6-13). Since the metabolic clearance rate of synthetic NT(6-13) in sheep was 30-fold higher than NT(1-13), it suggests that the elevated plasma levels are the result of impaired clearance and/or markedly elevated production.
神经降压素（6 - 13）已从人肝脏纤维板层癌中分离出来并测序，它是神经降压素样免疫反应性物质（NTLI）的主要形式。该患者循环中的NTLI，尤其是C末端，水平非常高。在进一步的研究中，合成了神经降压素（6 - 13），并通过高效液相色谱分析以及体外血浆稳定性测试，将其与纯化的肿瘤NTLI进行比较。这些方法证实肿瘤NTLI与神经降压素（6 - 13）相同。由于合成的神经降压素（6 - 13）在绵羊体内的代谢清除率比神经降压素（1 - 13）高30倍，这表明血浆水平升高是清除受损和/或生成显著增加的结果。
