Muraki K, Nishi Y, Okahata H, Arai M, Yamada H, Fujita S, Miyachi Y, Ueda K, Yamawaki S, Yajima H
Life Sci. 1987 Apr 6;40(14):1365-70. doi: 10.1016/0024-3205(87)90326-2.
Neurotensin-like immunoreactivity (NTLI) concentrations in the cerebrospinal fluid (CSF) of normal children and patients with febrile aseptic meningitis, aged 7 months to 15 years, were studied. The NTLI concentrations in CSF of 27 children with normal CSF findings were 160.1 +/- 54.6 pg/ml (mean +/- S.D.). The NTLI concentration in CSF of 26 patients in an acute phase of aseptic meningitis was 110.6 +/- 51.1 pg/ml which was significantly (P less than 0.01) lower than the controls. These patients had a mean temperature of 101.4 +/- 1.5 degrees F which remained elevated for an average of 3.5 days. The NTLI concentrations in CSF of 23 patients in a recovery phase (after blood and CSF findings became normal with no fever) were 166.5 +/- 57.8 pg/ml, which did not differ significantly from the normal. There were no statistical correlations between the NTLI concentration in CSF and the protein concentration or total cell count in CSF. These results suggest that NTLI concentration changes during a febrile aseptic meningitis and that it may be associated with thermoregulation.
对7个月至15岁的正常儿童和发热性无菌性脑膜炎患者脑脊液（CSF）中的神经降压素样免疫反应性（NTLI）浓度进行了研究。27例脑脊液检查结果正常的儿童脑脊液中NTLI浓度为160.1±54.6 pg/ml（平均值±标准差）。26例无菌性脑膜炎急性期患者脑脊液中NTLI浓度为110.6±51.1 pg/ml，显著低于对照组（P<0.01）。这些患者的平均体温为101.4±1.5华氏度，平均持续升高3.5天。23例恢复期患者（血液和脑脊液检查结果恢复正常且无发热）脑脊液中NTLI浓度为166.5±57.8 pg/ml，与正常组无显著差异。脑脊液中NTLI浓度与脑脊液中的蛋白质浓度或总细胞计数之间无统计学相关性。这些结果表明，发热性无菌性脑膜炎期间NTLI浓度会发生变化，并且可能与体温调节有关。
