Kumar G, Murugesan A G, Rajasekara Pandian M
Manonmaniam Sundaranar University, Sri Paramakalyani Centre for Environmental Science, Alwarkurichi, India.
Pharmazie. 2006 Apr;61(4):353-5.
The effect of oral administration of an aqueous extract of the bark of Helicteres isora was investigated on blood glucose and plasma antioxidant status in streptozotocin (STZ) induced diabetic rats. The study was also undertaken to evaluate the role of hepatic enzymes in experimental diabetes. Oral administration of a bark extract of Helicteres isora (100, 200 mg/kg) in STZ diabetic rats caused a significant increase in body weight, hepatic hexokinase activity and significant decrease in hepatic glucose-6-phosphatase, serum acid phosphatase (ACP), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). Based on these findings, we suggest that Helicteres isora possesses hypoglycemic and hepatoprotective activity and is able to ameliorate biochemical damage in STZ induced diabetic rats.
研究了口服艾地堇树皮水提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠血糖和血浆抗氧化状态的影响。该研究还旨在评估肝酶在实验性糖尿病中的作用。给STZ糖尿病大鼠口服艾地堇树皮提取物（100、200mg/kg）可导致体重显著增加、肝己糖激酶活性显著升高，以及肝葡萄糖-6-磷酸酶、血清酸性磷酸酶（ACP）、碱性磷酸酶（ALP）和乳酸脱氢酶（LDH）显著降低。基于这些发现，我们认为艾地堇具有降血糖和肝保护活性，并且能够改善STZ诱导的糖尿病大鼠的生化损伤。
