de Sousa Damião Pergentino, Gonçalves Juan Carlos Ramos, Quintans-Júnior Lucindo, Cruz Jader Santos, Araújo Demétrius Antonio Machado, de Almeida Reinaldo Nóbrega
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba (LTF/UFPB), 58051-900, João Pessoa, PB, Brazil.
Neurosci Lett. 2006 Jul 3;401(3):231-5. doi: 10.1016/j.neulet.2006.03.030. Epub 2006 May 2.
Citronellol is one monoterpene alcohol, which is present in the essential oils of various aromatic plant species. This study evaluated the neuroprotective activity of citronellol on pentylenetetrazol- and picrotoxin-induced convulsions and maximal electroshock-induced seizures in mice. Administration of citronellol significantly reduced the number of animals of convulsion induced by pentylenetetrazol and eliminated the extensor reflex of maximal electroshock-induced seizures test in about 80% of the experimental animals. In addition, administration of citronellol showed protection in the pentylenetetrazol and picrotoxin tests by increasing the latency of clonic seizures. We also investigated the effect of citronellol in the rat isolated nerve using the single sucrose-gap technique. We showed that the amplitude of the compound action potential decreased more than 90% when the monoterpene was incubated for 30 min at 6.4 mM and we did not verify any effect on the repolarization of the compound action potential. Taken together, our results demonstrated an anticonvulsant activity of the citronellol that could be, at least in part, explained by the diminution of the action potential amplitude.
香茅醇是一种单萜醇，存在于多种芳香植物物种的精油中。本研究评估了香茅醇对戊四氮和印防己毒素诱导的小鼠惊厥以及最大电休克诱导的癫痫发作的神经保护活性。给予香茅醇可显著减少戊四氮诱导惊厥的动物数量，并在约80%的实验动物中消除最大电休克诱导癫痫发作试验中的伸肌反射。此外，给予香茅醇在戊四氮和印防己毒素试验中通过增加阵挛性发作的潜伏期表现出保护作用。我们还使用单蔗糖间隙技术研究了香茅醇对大鼠离体神经的影响。我们发现，当该单萜在6.4 mM浓度下孵育30分钟时，复合动作电位的幅度下降超过90%，并且我们未证实其对复合动作电位复极化有任何影响。综上所述，我们的结果表明香茅醇具有抗惊厥活性，这至少部分可以通过动作电位幅度的减小来解释。
