Quintans-Júnior L J, Souza T T, Leite B S, Lessa N M N, Bonjardim L R, Santos M R V, Alves P B, Blank A F, Antoniolli A R
Departamento de Fisiologia, Universidade Federal de Sergipe, Campus Universitário Prof. Aloísio de Campos, CEP 49100-000 São Cristóvão, SE, Brazil.
Phytomedicine. 2008 Aug;15(8):619-24. doi: 10.1016/j.phymed.2007.09.018. Epub 2007 Oct 31.
Cymbopogon winterianus (Poaceae) is used for its analgesic, anxiolytic and anticonvulsant properties in Brazilian folk medicine. This report aimed to perform phythochemical screening and to investigate the possible anticonvulsant effects of the essential oil (EO) from fresh leaves of C. winterianus in different models of epilepsy. The phytochemical analysis of EO showed presence of geraniol (40.06%), citronellal (27.44%) and citronellol (10.45%) as the main compounds. A behavioral screening demonstrated that EO (100, 200 and 400mg/kg; ip) caused depressant activity on CNS. When administered concurrently, EO (200 and 400mg/kg, ip) significantly reduced the number of animals that exhibited PTZ- and PIC-induced seizures in 50% of the experimental animals (p<0.05). Additionally, EO (100, 200 and 400mg/kg, ip) significantly increased (p<0.05) the latencies of clonic seizures induced by STR. Our results demonstrated a possible activity anticonvulsant of the EO.
在巴西民间医学中，香茅（禾本科）因其具有止痛、抗焦虑和抗惊厥特性而被使用。本报告旨在进行植物化学筛选，并研究香茅新鲜叶片精油（EO）在不同癫痫模型中可能的抗惊厥作用。对EO的植物化学分析表明，香叶醇（40.06%）、香茅醛（27.44%）和香茅醇（10.45%）为主要成分。行为学筛选表明，EO（100、200和400mg/kg；腹腔注射）对中枢神经系统有抑制活性。同时给药时，EO（200和400mg/kg，腹腔注射）显著降低了50%实验动物中出现戊四氮和印防己毒素诱发惊厥的动物数量（p<0.05）。此外，EO（100、200和400mg/kg，腹腔注射）显著增加（p<0.05）了由士的宁诱发的阵挛性惊厥的潜伏期。我们的结果证明了EO可能具有抗惊厥活性。
